Technical Info
Scientific Info
Changes in circulating vitamin D levels with loss of adipose tissue.


Curr Opin Clin Nutr Metab Care. 2016 Aug 16.

Gangloff A1, Bergeron J, Lemieux I, Després JP.

Author information



Low vitamin D levels have been extensively reported in obesity. Thus, the pandemic of obesity has been paralleled by a high prevalence of low vitamin D status. Given the well documented associations linking poor vitamin D status to adverse health outcomes (diabetes, cardiovascular disease, cancers, all-cause mortality), a proper understanding of the mechanisms linking excess adiposity to low vitaminD status is key to identify and implement effective interventions to replenish vitamin D levels in obese individuals. In this review, we will discuss recent literature investigating the effects of adipose tissue volume loss through energy restriction and/or physical activity on circulating 25-hydroxyvitamin D [25(OH)D] levels.


Improvements of circulating 25(OH)D levels with adiposity loss through lifestyle interventions without supplementation is being reported by a growing number of studies, including recent randomized controlled trials.


Low 25(OH)D is one of the metabolic disturbances associated with excess adiposity, particularly visceral adiposity. Recommendations for the treatment of obesity-related vitamin D deficiency should emphasize the role of visceral adiposity loss through healthy lifestyle habits, in conjunction with weight-adjusted vitamin D supplementation, not only to replenish 25(OH)D levels but also to address other visceral adiposity-related disturbances, such as insulin resistance, inflammation, hypertension, and dyslipidemia.

  • Add:Rm.420-448,4th Floor, Bldg.B4,No.11,Kaiyuan Avenue,Guangzhou Hi-tech Industrial Zone
  • Tel:020-32068509 Fax:020-32068477
  • Mob:18922438286

Copyright © Guangzhou Phicon Biotech Co.,Ltd All rights reserved. 粤ICP备15043610号-1

QQ online
Consultation hotline
Phone consultation